USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: P30153 USC-OGP 2-DE database:  P30153 P30153 General information about the entry View entry in simple text format Entry name 2AAA_HUMAN Primary accession number P30153 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform; AltName: Full=Medium tumor antigen-associated 61 kDa protein; AltName: Full=PP2A subunit A isoform PR65-alpha; AltName: Full=PP2A subunit A isoform R1-alpha;. Gene name Name=PPP2R1A Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_4-5 {PLATELET 4-5} Homo sapiens (Human)   map experimental info   PLATELET_4-5 MAP LOCATIONS: SPOT OGP-0040: pI=5.00; Mw=61375 Cross-references UniProtKB/Swiss-Prot P30153; 2AAA_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name 2AAA_HUMAN Primary accession number P30153 Secondary accession number(s) Q13773 Q6ICQ3 Q96DH3 Sequence was last modified on  April 3, 2007 (version 4) Annotations were last modified on  March 15, 2017 (version 180) Name and origin of the protein Description RecName: Full=Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform; AltName: Full=Medium tumor antigen-associated 61 kDa protein; AltName: Full=PP2A subunit A isoform PR65-alpha; AltName: Full=PP2A subunit A isoform R1-alpha; Gene name Name=PPP2R1A Encoded on Name=PPP2R1A Keywords 3D-structure; Acetylation; Centromere; Chromosome; Chromosome partition; Complete proteome; Cytoplasm; Direct protein sequencing; Disease mutation; Mental retardation; Reference proteome; Repeat. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL M31786; AAA35531.1; -; mRNA EMBL J02902; AAA36399.1; -; mRNA EMBL CR450340; CAG29336.1; -; mRNA EMBL BC001537; AAH01537.1; -; mRNA CCDS CCDS12849.1; -; . PIR A34541; A34541; . RefSeq NP_055040.2; NM_014225.5; . UniGene Hs.467192; -; . PDB 1B3U; X-ray; 2.30 A; A/B=2-589 PDB 2IE3; X-ray; 2.80 A; A=1-589 PDB 2IE4; X-ray; 2.60 A; A=1-589 PDB 2NPP; X-ray; 3.30 A; A/D=1-589 PDB 2NYL; X-ray; 3.80 A; A/D=8-589 PDB 2NYM; X-ray; 3.60 A; A/D=8-589 PDB 2PKG; X-ray; 3.30 A; A/B=10-589 PDB 3C5W; X-ray; 2.80 A; A=9-589 PDB 3DW8; X-ray; 2.85 A; A/D=9-589 PDB 3K7V; X-ray; 2.85 A; A=1-589 PDB 3K7W; X-ray; 2.96 A; A=1-589 PDB 4I5L; X-ray; 2.43 A; A/D=6-589 PDB 4I5N; X-ray; 2.80 A; A/D=6-589 PDB 4LAC; X-ray; 2.82 A; A=404-589 PDBsum 1B3U; -; . PDBsum 2IE3; -; . PDBsum 2IE4; -; . PDBsum 2NPP; -; . PDBsum 2NYL; -; . PDBsum 2NYM; -; . PDBsum 2PKG; -; . PDBsum 3C5W; -; . PDBsum 3DW8; -; . PDBsum 3K7V; -; . PDBsum 3K7W; -; . PDBsum 4I5L; -; . PDBsum 4I5N; -; . PDBsum 4LAC; -; . ProteinModelPortal P30153; -; . SMR P30153; -; . BioGrid 111510; 272; . DIP DIP-29394N; -; . IntAct P30153; 187; . MINT MINT-1141071; -; . STRING 9606.ENSP00000324804; -; . iPTMnet P30153; -; . PhosphoSitePlus P30153; -; . SwissPalm P30153; -; . BioMuta PPP2R1A; -; . DMDM 143811355; -; . OGP P30153; -; . REPRODUCTION-2DPAGE IPI00554737; -; . EPD P30153; -; . MaxQB P30153; -; . PaxDb P30153; -; . PeptideAtlas P30153; -; . PRIDE P30153; -; . DNASU 5518; -; . Ensembl ENST00000322088; ENSP00000324804; ENSG00000105568; . GeneID 5518; -; . KEGG hsa:5518; -; . UCSC uc002pyp.4; human; . CTD 5518; -; . DisGeNET 5518; -; . GeneCards PPP2R1A; -; . HGNC HGNC:9302; PPP2R1A; . HPA CAB018599; -; . MalaCards PPP2R1A; -; . MIM 605983; gene; . MIM 616362; phenotype; . neXtProt NX_P30153; -; . OpenTargets ENSG00000105568; -; . PharmGKB PA33666; -; . eggNOG KOG0211; Eukaryota; . eggNOG ENOG410XQVI; LUCA; . GeneTree ENSGT00730000110944; -; . HOGENOM HOG000078539; -; . HOVERGEN HBG000011; -; . InParanoid P30153; -; . KO K03456; -; . OMA MSNILPC; -; . OrthoDB EOG091G045V; -; . PhylomeDB P30153; -; . TreeFam TF105552; -; . BioCyc MetaCyc:ENSG00000105568-MONOMER; -; . Reactome R-HSA-113501; Inhibition of replication initiation of damaged DNA by RB1/E2F1; . Reactome R-HSA-1295596; Spry regulation of FGF signaling; . Reactome R-HSA-163685; Integration of energy metabolism; . Reactome R-HSA-163767; PP2A-mediated dephosphorylation of key metabolic factors; . Reactome R-HSA-180024; DARPP-32 events; . Reactome R-HSA-195253; Degradation of beta-catenin by the destruction complex; . Reactome R-HSA-196299; Beta-catenin phosphorylation cascade; . Reactome R-HSA-198753; ERK/MAPK targets; . Reactome R-HSA-202670; ERKs are inactivated; . Reactome R-HSA-2465910; MASTL Facilitates Mitotic Progression; . Reactome R-HSA-2467813; Separation of Sister Chromatids; . Reactome R-HSA-2500257; Resolution of Sister Chromatid Cohesion; . Reactome R-HSA-2565942; Regulation of PLK1 Activity at G2/M Transition; . Reactome R-HSA-2995383; Initiation of Nuclear Envelope Reformation; . Reactome R-HSA-380259; Loss of Nlp from mitotic centrosomes; . Reactome R-HSA-380270; Recruitment of mitotic centrosome proteins and complexes; . Reactome R-HSA-380284; Loss of proteins required for interphase microtubule organization from the centrosome; . Reactome R-HSA-389513; CTLA4 inhibitory signaling; . Reactome R-HSA-432142; Platelet sensitization by LDL; . Reactome R-HSA-4641262; Disassembly of the destruction complex and recruitment of AXIN to the membrane; . Reactome R-HSA-5339716; Misspliced GSK3beta mutants stabilize beta-catenin; . Reactome R-HSA-5358747; S33 mutants of beta-catenin aren't phosphorylated; . Reactome R-HSA-5358749; S37 mutants of beta-catenin aren't phosphorylated; . Reactome R-HSA-5358751; S45 mutants of beta-catenin aren't phosphorylated; . Reactome R-HSA-5358752; T41 mutants of beta-catenin aren't phosphorylated; . Reactome R-HSA-5467337; APC truncation mutants have impaired AXIN binding; . Reactome R-HSA-5467340; AXIN missense mutants destabilize the destruction complex; . Reactome R-HSA-5467348; Truncations of AMER1 destabilize the destruction complex; . Reactome R-HSA-5620912; Anchoring of the basal body to the plasma membrane; . Reactome R-HSA-5663220; RHO GTPases Activate Formins; . Reactome R-HSA-5673000; RAF activation; . Reactome R-HSA-5675221; Negative regulation of MAPK pathway; . Reactome R-HSA-6804757; Regulation of TP53 Degradation; . Reactome R-HSA-6811558; PI5P; PP2A and IER3 Regulate PI3K/AKT Signaling; . Reactome R-HSA-68877; Mitotic Prometaphase; . Reactome R-HSA-69231; Cyclin D associated events in G1; . Reactome R-HSA-69273; Cyclin A/B1 associated events during G2/M transition; . Reactome R-HSA-70171; Glycolysis; . Reactome R-HSA-8854518; AURKA Activation by TPX2; . Reactome R-HSA-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); . SignaLink P30153; -; . SIGNOR P30153; -; . ChiTaRS PPP2R1A; human; . EvolutionaryTrace P30153; -; . GeneWiki PPP2R1A; -; . GenomeRNAi 5518; -; . PMAP-CutDB P30153; -; . PRO PR:P30153; -; . Proteomes UP000005640; Chromosome 19; . Bgee ENSG00000105568; -; . CleanEx HS_PPP2R1A; -; . ExpressionAtlas P30153; baseline and differential; . Genevisible P30153; HS; . GO GO:0000775; C:chromosome; centromeric region; IDA:UniProtKB GO GO:0005829; C:cytosol; TAS:UniProtKB; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0016020; C:membrane; NAS:UniProtKB; . GO GO:0015630; C:microtubule cytoskeleton; NAS:UniProtKB; . GO GO:0005739; C:mitochondrion; NAS:UniProtKB; . GO GO:0005634; C:nucleus; NAS:UniProtKB; . GO GO:0000159; C:protein phosphatase type 2A complex; IDA:UniProtKB; . GO GO:0003823; F:antigen binding; IPI:UniProtKB; . GO GO:0046982; F:protein heterodimerization activity; IPI:UniProtKB; . GO GO:0019888; F:protein phosphatase regulator activity; TAS:UniProtKB; . GO GO:0004722; F:protein serine/threonine phosphatase activity; IEA:Ensembl; . GO GO:0006915; P:apoptotic process; TAS:UniProtKB; . GO GO:0006672; P:ceramide metabolic process; NAS:UniProtKB; . GO GO:0007059; P:chromosome segregation; IDA:UniProtKB; . GO GO:0097711; P:ciliary basal body docking; TAS:Reactome; . GO GO:0007143; P:female meiotic division; IEA:Ensembl; . GO GO:0000086; P:G2/M transition of mitotic cell cycle; TAS:Reactome; . GO GO:0000188; P:inactivation of MAPK activity; NAS:UniProtKB; . GO GO:0051754; P:meiotic sister chromatid cohesion; centromeric; IEA:Ensembl GO GO:0051232; P:meiotic spindle elongation; IEA:Ensembl; . GO GO:0007084; P:mitotic nuclear envelope reassembly; TAS:Reactome; . GO GO:0051306; P:mitotic sister chromatid separation; IEA:Ensembl; . GO GO:0030308; P:negative regulation of cell growth; NAS:UniProtKB; . GO GO:0042518; P:negative regulation of tyrosine phosphorylation of Stat3 protein; NAS:UniProtKB; . GO GO:0000184; P:nuclear-transcribed mRNA catabolic process; nonsense-mediated decay; TAS:Reactome GO GO:0070262; P:peptidyl-serine dephosphorylation; IEA:Ensembl; . GO GO:2001241; P:positive regulation of extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl; . GO GO:0006461; P:protein complex assembly; TAS:UniProtKB; . GO GO:0006470; P:protein dephosphorylation; TAS:UniProtKB; . GO GO:0030155; P:regulation of cell adhesion; NAS:UniProtKB; . GO GO:0045595; P:regulation of cell differentiation; NAS:UniProtKB; . GO GO:0006275; P:regulation of DNA replication; NAS:UniProtKB; . GO GO:0040008; P:regulation of growth; NAS:UniProtKB; . GO GO:1903538; P:regulation of meiotic cell cycle process involved in oocyte maturation; IEA:Ensembl; . GO GO:0006355; P:regulation of transcription; DNA-templated; NAS:UniProtKB GO GO:0030111; P:regulation of Wnt signaling pathway; NAS:UniProtKB; . GO GO:0010033; P:response to organic substance; NAS:UniProtKB; . GO GO:0008380; P:RNA splicing; NAS:UniProtKB; . GO GO:0019932; P:second-messenger-mediated signaling; NAS:UniProtKB; . Gene3D 1.25.10.10; -; 1; . InterPro IPR011989; ARM-like; . InterPro IPR016024; ARM-type_fold; . InterPro IPR000357; HEAT; . InterPro IPR021133; HEAT_type_2; . InterPro IPR031090; PP2A_A_meta; . PANTHER PTHR10648:SF16; PTHR10648:SF16; 1; . Pfam PF02985; HEAT; 1; . SUPFAM SSF48371; SSF48371; 1; . PROSITE PS50077; HEAT_REPEAT; 11; .

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